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KMID : 0390220030140010076
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Journal of Clinical Otolaryngology, Head and Neck Surgery
2003 Volume.14 No. 1 p.76 ~ p.80
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Expressive Pattern of Bcl-2, Bax and Fas in Nasal Polyp
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Lee Jae-Hoon
Choi Tae-Wook
Yun Ki-Jung
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Abstract
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Background and Objectives：Nasal polyp is non-neoplastic, chronic inflammatory disease of the nasal mucosa. Their formation may be associated with allergy or inflammation. Bcl-2 is known as anti-apoptotic gene, whereas Bax and Fas are known as pro-apoptotic genes. To illustrate the role of the Bcl-2, Bax and Fas in the pathogenesis of nasal polyp, we investigated expressive pattern of the Bcl-2, Bax and Fas in nasal polyp. Materials and Methods：The study samples were obtained after surgical removal of 19 cases of nasal polyp and 13 cases of normal nasal mucosa in the inferior turbinate as a control. The Bcl-2, Bax and Fas expressions were assessed by immunohistochemical staining. Result：The Bcl-2, Bax and Fas were expressed at seromucinous gland and cytoplasm of respiratory epithelium of nasal polyp and normal control. Only the Bcl-2 expression of nasal polyp was significantly decreased compared to normal control (p=0.0001). Conclusion：This study suggests that apoptosis inhibition by the Bcl-2 may be not related to the formation of nasal polyp.
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KEYWORD
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Nasal polyp, Bcl-2, Bax, Fas, Apoptosis
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